
See it in action
Discover Next-Gen Skincare, Backed by Biotech
90%
of participants showed visible improvement by week 12*
73%
of performance indicators showed DRMTLGY outperformed SkinMedica's $295 TNS Advanced+ Serum*
30%
greater visible improvement than SkinMedica's $295 TNS Advanced+ Serum*
*Based on a 12 week double-blind IRB-approved clinical trial of 20 participants.
4 Reasons You’ll Love Needle-less® Growth Factor Serum
001 Mimics the Skin's Natural Regenerative Signals
001 Mimics the Skin's Natural Regenerative Signals
A blend of 5 bio-engineered growth factor peptides mimics your skin’s repair messengers, encouraging faster cell renewal without the use of human-derived ingredients.
002 Visibly Lifts & Firms
002 Visibly Lifts & Firms
Clinically tested to deliver real results. 90% of participants noticed skin felt firmer, improved clarity & tone, and an improvement in overall appearance in just 12 weeks.*
003 Outperformed the Leading Growth Factor Serum at ¼ the price
003 Outperformed the Leading Growth Factor Serum at ¼ the price
In a 12-week IRB-approved, randomized, double-blinded, controlled clinical trial, our formula delivered 30% greater overall visible improvement, without the $295 price tag.
004 Repairs & Strengthens Skin Barrier
004 Repairs & Strengthens Skin Barrier
This serum features our CeraPep™ Technology, a proprietary blend of ceramides and peptides that restores the barrier’s essential lipids. So not only does this all-new formula lift and firm, but it’s proven to strengthen skin’s barrier after just one use.
THE SCIENCE BEHIND THE FORMULA
Dr. Dayan on Needle-less® Growth Factor Serum:
“In this 12-week clinical study, participants were split into two groups—each applying a different topical treatment twice daily. Preliminary results showed visible improvements in wrinkles, texture, and firmness across both groups. One group used DRMTLGY's product, while the other usedSkinMedica’s TNS Advanced+ Serumpriced 4x more. However, the formula developed by DRMTLGY demonstrated notably superior results in skin texture and firmness.”
--Dr. Steven H. Dayan MD, FACS
Collapsible content
Full Description
Full Description
The problem with most anti-aging serums is simple: they promise results but rarely prove they work. Many claim to smooth, firm, and lift—but where’s the evidence?
When we created Needle-less® Growth Factor Serum, we set out to do things differently. Instead of adding just another product to the lineup, we took a smarter approach—grounded in advanced technology and proven by real clinical testing.
In a 12-week, double-blind, IRB-approved clinical trial, Needle-less® Growth Factor Serum was tested head-to-head against SkinMedica’s TNS Advanced+ Serum, the industry’s best-known growth factor serum (sold at nearly 4x the price). The results spoke for themselves:
- Investigator-assessed improvements in skin texture and firmness were significantly higher for Needle-less® at both Week 8 and Week 12
- On the Global Aesthetic Improvement Scale (GAIS) at Week 12, Needle-less® Growth Factor Serum showed 30% greater overall improvement than the competitor
- It outperformed the leading growth factor serum in 73% of performance indicators
In other words, this isn’t just another serum with empty promises. It’s clinically proven skincare technology that reframes how we approach aging—helping skin look visibly lifted and visibly renewed.
Directions
Directions
Directions
Apply 1-2 pumps to clean skin in the morning or evening. Can be used daily or as directed by a physician.
Ingredients
Ingredients
Ingredients
Ingredient Highlights: Sodium Hyaluronate, Palmitoyl Tripeptide-1, Oligopeptide-3, Oligopeptide-2, Oligopeptide-1, Hexapeptide-11, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Ceramide NP, Folic Acid, Phytosphingosine, Ceramide AP, Ceramide EOP, Chiretta (Swertia Chirata) Extract, Mushroom (Tremella Fuciformis) Sporocarp Extract
All Ingredients: Water/Aqua/Eau, Glycerin, Butylene Glycol, Pentylene Glycol, Maltodextrin, Coco-Caprylate/Caprate, Saccharide Isomerate, Sodium Hyaluronate, Palmitoyl Tripeptide-1, Oligopeptide-3, Oligopeptide-2, Oligopeptide-1, Hexapeptide-11, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Ceramide NP, Folic Acid, Phytosphingosine, Ceramide AP, Ceramide EOP, Triheptanoin, Chiretta (Swertia Chirata) Extract, Phenoxyethanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C9-12 Alkane, Polyurethane-100, Ethylhexylglycerin, Sodium Hydroxide, Lecithin, Trisodium Ethylenediamine Disuccinate, Acetyl Glutamine, 1,2-Hexanediol, Mushroom (Tremella Fuciformis) Sporocarp Extract, Hydrolyzed Hyaluronic Acid, Decyl Glucoside, Bacillus/Soybean Ferment Extract, Sodium Lauroyl Lactylate, Caprylyl Glycol, Carbomer, Polysorbate 20, Cholesterol, Xanthan Gum
DRMTLGY is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
How to Layer Needle-less® Growth Factor Serum
Lightweight Formula for Everyday Skincare
Designed to fit seamlessly into any skincare routine, this serum absorbs comfortably into the skin without feeling heavy or greasy. Apply 1–2 pumps to clean skin in the morning or evening, allowing the advanced ingredients to support your daily skin renewal routine.
Suitable for a variety of skin types, including normal, oily, dry, and combination skin, it can be incorporated into routines focused on improving the appearance of wrinkles, firmness, texture, and dullness.
A New Chapter in Skin Renewal
Powered by advanced growth factor technology, Needle-less® Growth Factor Serum blends science and skincare to support a smoother, firmer-looking complexion. With lightweight hydration and skin-renewing ingredients, it helps reveal a naturally refreshed glow while becoming an effortless step in your daily routine.
Frequently Asked Questions
What is Needle-less® Growth Factor Serum?
What is Needle-less® Growth Factor Serum?
Needle-less® Growth Factor Serum is an advanced skincare formula powered by bio-engineered growth factor peptides. It is designed to support the appearance of smoother, firmer, and more refreshed-looking skin while complementing your daily skincare routine.
How do growth factors benefit the skin?
How do growth factors benefit the skin?
Growth factors are natural skin-signaling ingredients that help support the skin’s renewal process. This serum uses advanced peptide technology to help improve the visible appearance of firmness, elasticity, texture, and overall skin quality.
Is this serum suitable for all skin types?
Is this serum suitable for all skin types?
Yes. The lightweight formula is designed for various skin types, including normal, dry, oily, and combination skin. It provides hydration while helping maintain a balanced, healthy-looking complexion.
What ingredients make this serum unique?
What ingredients make this serum unique?
The formula combines five bio-engineered growth factor peptides with skin-supporting ingredients such as ceramides and hyaluronic acid. Together, these ingredients help nourish the skin barrier and improve the appearance of fine lines and uneven texture.
How should I use Needle-less® Growth Factor Serum?
How should I use Needle-less® Growth Factor Serum?
Apply 1–2 pumps to clean, dry skin after cleansing and before moisturizer. Use consistently as part of your morning or evening skincare routine to help maintain a smoother and more radiant-looking complexion.